Looks almost like it’s not 100% cut, and the jagged bits/break outs are where the piece is broken out from the little uncut bits when you separate the shape from the board.
I’d first go with multiple passes, and be sure you have the material pinned down super flat. The PG settings are a great starting point, but feel free to adjust as needed to get what you need (off hand I don’t recall the settings for clean acrylic, but you may want to compare to blue to figure a range to test). As @Jules noted, if it’s not masked on the bottom side at least, that should help.
Be sure to jiggle the piece before trying to remove the material to make sure it’s fully cut (though complex shapes may not be able to do this). If in doubt, do another cutting pass, and if you’ve not yet moved it, it will just follow the same cut line.