I’m afraid I don’t follow the question?
To your earlier point, unfortunately, MDF is a great example where material from different vendors (and even different batches) can vary immensely in settings. For example, I bought some 1/4" MDF from Home Depot that I couldn’t cut through on my friend’s 100W machine! But I’ve found other 1/4" MDF that cuts just fine on a Glowforge.