I work for Intel and have been working on developing reference designs for autonomous robots (that is, robots capable of sensing their environment and navigating by themselves) using the RealSense 3D depth camera. I recently used a dozen of my robots, which uses a laser-cut frame, at the Intel Developer Forum in San Franscisco to give a hands-on lab.
A bit on my design process: I use OpenSCAD for the 3D modelling. This is a free procedural modelling system that lets me do useful things like intersect one plate with another in 3D so I can match up slots and tabs exactly. I can also do offsets and adjust bolt hole sizes precisely. I export the files as DXF and then import them into Inkscape to lay them out, and also to color them to control the cutting order (it is important for precision to cut interior features first before cutting the outer boundary and freeing the part from the sheet). I am currently using a Trotec laser cutter at my local makerspace, DMM.make in Tokyo, but am impatiently waiting for my GlowForge so I can work from home.
I should note that I cut parts in both Acyrlic and Delrin (aka POM or Duracon or Acetel). Acrylic is cheap and comes in a wide variety of colors both transparent and opaque, but can be brittle. For more durability I am now using Delrin, which also raises interesting possibilities for flexible joints so entire linkages (eg for grippers) can be cut rather than assembled.