I ordered a cactus leather sample kit from Desserto some time ago and, finally got around to trying it.
There is quite a bit of variability. Thickness ranges from about half a millimeter to 1.8 millimeters. Their catalog lists six different backing materials:
50% polyester / 50% cotton
65% polyester / 35% cotton
100% polyester
100% cotton
100% cotton “infused with cactus”
100% nylon
Some of the backing matches the material for color while others did not. There are, for instance, samples of dark material with matching backings and, similar dark material with white backings.
Less relevant for lasering, there are also several different surface finishes.
The bolts are 1.4 meters wide and, run between $22 and $52 USD per meter, depending on the specific configuration.
Vaporized material seems to re-deposit as a sticky goo on the surface. Masking mostly prevents that and, the goo will wash off with some mild soap (I used a foaming hand soap) and a bit of rubbing. Isopropyl alcohol can take it off, too but, will also damage the finish noticeably in some cases.
Given the range, my settings are probably of limited use but, I found the masked 1mm thick 50/50-blend-backed stuff cut at about 245/75. I got decent (masked) engraves at 1000/51/270LPI.
Filling engraves with acrylic paint (via Posca-style pens) worked pretty well. The surface also takes paint acceptably (sloppy test below). I bet it would screen print nicely.
I came up with a simple card case to make from one of the 10cm by 15cm samples. My paint fills could use some improvement but, it seems like it mostly handles as expected.
I made a 1 minute video summarizing all that, if that’s your jam: