That would look really nice. There was this thread where the OP was using an engrave and spray to create beautiful faux inlays: Laser-Assisted Creations (Jewelry Box, Beer Caddy, and Litter Box Bench)
I imagine you’d get a similar look on the acrylic and, if you built up your mask a bit before lasering/painting, you might be able to get a slightly raised surface for proper leading texture.