Perhaps. But it’s also a very efficient way to narrow things down to a machine issue, or end-user-error since it creates controlled testing conditions.
Just my opinion, this is something that should be done even if alignment is sub-millimeter accurate. Bleed exists for a reason and is used for basically all reproduction technology.
You mention that alignment is perfect on medium draftboard. Using Proofgrade materials isn’t doing anything “magic” for your alignment: it’s just using a known set of variables - which indicates that it is most likely user error that is leading to a negative experience.