A properly sealed and vented system should be the same as a filtered system, however, whenever you open the lid to the glowforge there is going to be some smell. There is always some residual odor. Also, the masking will pick up some of the odor so when you weed all that masking off seal it up in a plastic bag. Some people have more sensitive olfactory systems than others, so some people are more bothered by it than others; it all depends on the quality of your SO’s nose. Acrylic certainly has a different smell than wood and most people do not approve of it.
If your second bedroom has a door on it, and your ventilation system is properly sealed, I would think most of the odor, what there is of it, would stay in that room. Well, except for the part that clings to your hands. Wash them all you want, the final bit takes time. Maybe a lotion will help IDK.
As regards your neighbors, are you in a condo with neighbors above you or in a single family home out in the suburbs? What you vent outside is being dispersed into a very large volume of air, but not so large that it won’t bother neighbors if they live close enough to your vent. I have read of people living in apartments/condos with neighbors that have complained about both the smell and noise.