Tonight I discovered that if any of the artwork is out of bounds and in the grayed out area to the left and bottom of the work area that nothing will happen. You can click Print, it’ll scan your material and then nothing will happen. In my case I was trying to print a registration mark cross right at the 0,0 of the work area.
It might be worth coding the GFUI to prompt with a message to inform the users of this. Even better would be to warn the user of this, and then have the path processing to laser everything that is possible to be cut, and mask/clip whatever is out of bounds.
I figured it out, but felt other users would likely encounter this same problem.