My experience as follows: no matter what I tried in my laser room, every time I cut acrylic my whole house would smell like acrylic. I even put weather stripping on the door to the room, completely taped up plastic around the window (double window has a gap between the panes when opened), taped bubble wrap all around the dryer hose, and sealed the ends really well. My next step was to get metal ducting. The duct hose has been between 4 feet and 1ft in length, depending on me reorganizing.
Then the threads about an inline fan started popping up, and so I got a fan and a speed regulator. I had disassembled my setup completely for reorganization reasons, so as a minimum viable test, I took the new fan and wedged into the outside of the vent hole, sloppily slapped the abused dryer hose back on and tested an acrylic cut. To my surprise, the smell was drastically cut down, so I used electrical tape to tape the dryer hose onto the GF, and now sloppily slap it back together each time I laser, about 1- 2 times a week or so. No problem with acrylic smell in the rest of the house. Bonus, I can have the inline fan on with the 'forge off and leave the freshly cut and still stinky acrylic in the laser bed to air out some.
Moral to the story, is one get an inline fan, best GF purchase yet, and two electrical tape applied correctly works better than the metal compression ring or the worm gear clamp, and is much nicer to your knuckles!
“Applied correctly” means to stretch the tape while applying it