BTW, If you use acrylic for the letters, just thought I’d point out something I learned with my domino set. I used clear acrylic and then painted the dots / pips. They looked awesome. As @geek2nurse reminded me at the time, you can see the dominoes when you are choosing them. I had planned to paint over the dots with another color, but it was hard to do this with craft paint. I’m going to redo them with spray paint (just got busy with lots of other things so haven’t finished).
This is the plan I’m going to try next, maybe I’ll make this set or maybe I’ll just finish my domino set lol:
- Reverse the letters (this doesn’t apply for dominoes since they are just dots lol)
- When printing the letters, score them.
- Weed the inside of the letters and leave the rest of the squares masked.
- Lay the tiles out with printed side up. Spray the letters with spray paint. Let dry fully.
- Weed the remaining masking.
- Lay the tiles out again with the painted side up. Paint again with white spray paint or whatever color you want. Let dry fully.
The designs look so cool this way. But I don’t want to be able to see what I’m picking when the pieces are turned over. I need to teach my kids how to play right and not cheat. 
Anyway, if/when I end up trying this out, i’ll try to remember to update and share pics. (Maybe now that I’ve posted this comment, I’ll be motivated to do it soon. haha)