I have some 2 color 0.020 I got because the order was mangled. Got the order sorted but still had this ultra thin stuff to work with.
Decided to use for some inlay and went with the parameters below.
Cut 300/100 (also have 350/100 penciled here, but not remember if was used or needed)
Seemed to work ok, so I imagine it would be ok with clear or single color stuff.
As to masking, I remove it all normally, since it turns to into a gummy mess at times. Any laser char can usually be rubbed off using alcohol.
Only acrylic I mask is some 2 color blue marble looking stuff that had a lot of flare when cut (a LOT). Something to do with the coloring materials is my guess.