Hey folks–I recently watched a PBS special called The Origami Revolution, about the use of origami in science and engineering. It’s a pretty cool show, highly recommended.
Anyway, early in the show was a demonstration by Robert Lang, noted origami expert, where he designed crease patterns on computer then used his laser engraver/cutter to engrave the patterns into his large sheet of folding paper. He was able to get extremely complex models this way.
He has also made available his Treemaker software for designing your own crease patterns.