Something that isn’t covered here so far:
I cut 1/2 inch acrylic. It took four passes and I had to set up a custom support for it. What I found is that the acrylic holds so much heat inside that it will warp and start to smolder. If you want to cut it, plan on multiple passes, each with a wait time for the material to stabilize. You may still get movement. The thinner the area you want to retain the more it will move. On the part I did, anything thinner than 1/4 inch was moving all over the place to the point where sometimes the second pass or third pass was hitting material that had moved into the kerf.
So yes, you can do it, but don’t expect it to turn out perfectly the first time and be VERY careful.